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[37] Chakrabarti SK, Ghosh S, Banerjee S, Mukherjee S, Chowdhury S
4 The ATP production induces first-phase insulin secretion as the now raised ATP/ADP ratio in the cell leads to the closure of ATP-sensitive potassium channels, which then results in membrane depolarisation
Importantly, these recommendations are final FDA decisions, but they represent a meaningful shift in the regulatory landscape
In SURMOUNT-1 (NEJM 2022, 2,539 adults with obesity), the 15 mg arm averaged 22.5% body weight loss at 72 weeks, the 10 mg arm 21.4%, and the 5 mg arm 16.0%
